"Different brain systems are used when one produces lies in different ways, such as by fabricating lies spontaneously "on the fly" versus fabricating them on the basis of a previously memorized story. This discovery indicates that there is no single "lie center" in the brain, and makes it unlikely that a single neural pattern of activation can distinguish deception from telling the truth."
– Professor Stephen M. Kosslyn, Harvard University and Massachusetts General Hospital
Read more from the Berkman Center for Internet & Society at Harvard University>>
Site also includes an audio file and a PDF paper: Neural Correlates of Different Types of Deception: An fMRI Investigation (PDF file)>>